The 1913-S Type 2 Buffalo nickel is a scarce key-date coin with the third-lowest business-strike mintage of the series. Only 1,209,000 examples were made and only 14,000 specimens are estimated to survive, with about 1,800 known in uncirculated grades. In all grades, this piece is highly sought after by collectors. Desirable even in circulated grades, the 1913-S Type 2 Buffalo nickel is a particularly popular with date-and-mintmark set collectors and enjoys steady demand in the marketplace.

Uncirculated examples are plentiful through MS65, though it becomes far more difficult to locate in MS66 or higher. PCGS has graded only about half a dozen examples in MS67, presently representing the highest grade awarded by that TPG to any 1913-S Type 2 Buffalo nickel. For that reason, registry set collectors vie for the several dozen known MS66 pieces, which represent their own challenges but are far more affordable than the elusive, scarcely traded MS67s.